Group Sequential Methods with Applications to Clinical Trials

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Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

Group sequential methods answer the needs of clinical trial monitoring committees who must assess the data available at an interim analysis. These interim results may provide grounds for terminating the study-effectively reducing costs-or may benefit the general patient population by allowing early dissemination of its findings. Group sequential methods provide a means to balance the ethical and financial advantages of stopping a study early against the risk of an incorrect conclusion.
Group Sequential Methods with Applications to Clinical Trials describes group sequential stopping rules designed to reduce average study length and control Type I and II error probabilities. The authors present one-sided and two-sided tests, introduce several families of group sequential tests, and explain how to choose the most appropriate test and interim analysis schedule. Their topics include placebo-controlled randomized trials, bio-equivalence testing, crossover and longitudinal studies, and linear and generalized linear models.
Research in group sequential analysis has progressed rapidly over the past 20 years. Group Sequential Methods with Applications to Clinical Trials surveys and extends current methods for planning and conducting interim analyses. It provides straightforward descriptions of group sequential hypothesis tests in a form suited for direct application to a wide variety of clinical trials. Medical statisticians engaged in any investigations planned with interim analyses will find this book a useful and important tool.

Country	USA
Binding	Hardcover
Brand	Chapman and Hall/CRC
EAN	9780849303166
Edition	1
Genre	MATHEMATICS
ISBN	0849303168
IsEligibleForTradeIn	1
Label	Chapman and Hall/CRC
Manufacturer	Chapman and Hall/CRC
MPN	69 black & white tables
NumberOfItems	1
NumberOfPages	416
PartNumber	69 black & white tables
PublicationDate	1999-09-15
Publisher	Chapman and Hall/CRC
Studio	Chapman and Hall/CRC
ReleaseDate	0000-00-00

Group Sequential Methods with Applications to Clinical Trials (Chapman & Hall/CRC Interdisciplinary Statistics)

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